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October 1, 1985Journal of Clinical InvestigationOpen Access

Possible role of adenosine in the macula densa mechanism of renin release in rabbits.

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Why the study?

Does adenosine decrease renin release via A1 receptors and act as an inhibitory signal from the macula densa to juxtaglomerular cells?

Population

Microdissected afferent arterioles alone and afferent arterioles with macula densa attached from young male…

Comparison

Adenosine, N6-cyclohexyl adenosine… vs Time control or no pretreatment.

Design

Preclinical

Follow-up

30-min incubation periods

Authors

SISadayoshi ItoOCOscar A. CarreteroRMRobert Murray

Discussion

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Overview

Supports A1-mediated renin suppression in rodent preparations; leaves open translation to human macula densa–juxtaglomerular signaling.

Structured PICO

Does adenosine decrease renin release via A1 receptors and act as an inhibitory signal from the macula densa to juxtaglomerular cells?

P
Population
Microdissected afferent arterioles (Af) alone and afferent arterioles with macula densa attached (Af + MD) from young male New Zealand White rabbits (1.5-2.5 kg) maintained on a low sodium diet.
I
Intervention
Adenosine (0.1 μM and 10 μM), N6-cyclohexyl adenosine (0.1 μM and 10 μM), 5'-N-ethylcarboxamide adenosine (0.1 μM and 10 μM), and theophylline (10 μM) added to incubation medium.
C
Comparator
Time control (basal renin release rate) or no pretreatment.
O
Outcome
Hourly renin release rate from a single arteriole (or an arteriole with macula densa), expressed as ng AI × h-1 × Af-1 (or Af + MD-1)/h.surrogate

Adenosine decreases renin release via the activation of A1 adenosine receptors and may serve as an inhibitory signal from the macula densa to juxtaglomerular cells.

Limitations

  • In vitro preparation exposes macula densa to medium sodium chloride concentrations much higher than in vivo early distal tubular urine
  • Further experiments necessary to test the hypothesis in vivo

Cite This Study

Ito et al. (1985) studied this question.

synapsesocial.com/papers/6a8347eb2b7aeacfa1d9cc98https://doi.org/10.1172/jci112118
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