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April 1, 2003AJP Renal Physiology

Preserved macula densa-dependent renin secretion in A1adenosine receptor knockout mice

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Key result

Adenosine A1 receptor (A1AR) knockout mice showed markedly enhanced stimulation of Ren-1 mRNA expression and renal renin content by salt restriction compared with wild-type mice.

Population

A1AR(+/+), A1AR(+/-), and A1AR(-/-) mice

Comparison

Dietary salt manipulation and pharmacological… vs Wild-type (A1AR+/+) mice

Design

Preclinical

Follow-up

up to 1 week

Authors

FSFrank SchwedaCWCharlotte WagnerBKBernhard K. Krämer

Discussion

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Overview

Supports tonic A1AR inhibition of renin; extends animal mechanistic data but leaves open human relevance.

Structured PICO

P
Population
A1AR(+/+), A1AR(+/-), and A1AR(-/-) mice
E
Exposure
Dietary salt manipulation (high-salt diet for 1 week, salt restriction) and pharmacological blockade with loop diuretics (furosemide 1.2 mg/day for 6 days in vivo, bumetanide 100 microM in isolated perfused kidneys)
C
Comparator
Wild-type (A1AR+/+) mice
O
Outcome
Renin mRNA expression and renal renin contentsurrogate

The adenosine A1 receptor exerts a tonic inhibitory role in the renin system but is not indispensable for macula densa control of renin secretion.

Cite This Study

Schweda et al. (2003) studied this question. Adenosine A1 receptor (A1AR) knockout vs. Wild-type mice was evaluated on Renin mRNA expression and renal renin content. Adenosine A1 receptor (A1AR) knockout mice showed markedly enhanced stimulation of Ren-1 mRNA expression and renal renin content by salt restriction compared with wild-type mice.

synapsesocial.com/papers/6a842f00a47fb2e1cdb29a33https://doi.org/10.1152/ajprenal.00280.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Possible role of adenosine in the macula densa mechanism of renin release in rabbits.1985 · 68 citations
  2. 2Effects of Furosemide and Verapamil on the NaCl Dependency of Macula Densa–Mediated Renin Secretion1995 · 90 citations
  3. 3Blood Pressure, Cardiac, and Renal Responses to Salt and Deoxycorticosterone Acetate in Mice2002 · 77 citations
  4. 4Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport1991 · 179 citations
  5. 5Juxtaglomerular cell complex in the regulation of renal salt excretion1998 · 233 citations