Key result
Angiotensin II infusion in male Wistar rats significantly increased renal interstitial adenosine compared to sham (62.0 vs 31.40 nM; P<0.001), contributing to renal vasoconstriction.
Population
Male Wistar rats
Comparison
Angiotensin II infusion via osmotic minipumps… vs Sham group
Design
Preclinical
Follow-up
14 days
Authors
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Should not alter hypertension management; hypothesis-generating for adenosine's role in rodent Ang II models.
Absolute Event Rate: 62% vs 31.4%
p-value: p=< 0.001
In a rat model of ANG II-induced hypertension, elevated renal interstitial adenosine contributes to renal vasoconstriction, mediated by decreased ADA activity and altered adenosine receptor expression.
Franco et al. (2007) studied Angiotensin II-induced hypertension. Angiotensin II vs. Sham was evaluated on Renal interstitial adenosine (nM) (p=< 0.001). Angiotensin II infusion in male Wistar rats significantly increased renal interstitial adenosine compared to sham (62.0 vs 31.40 nM; P<0.001), contributing to renal vasoconstriction.
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