Key result
Although acute infusion of angiotensin II at 10 ng/min elevated plasma adenosine in anesthetized rats, chronic elevation of angiotensin II did not increase plasma adenosine in conscious, unrestrained rats.
Population
Anesthetized rats and conscious, unrestrained rats
Design
Preclinical
Authors
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Chronic angiotensin II does not raise plasma adenosine in conscious rats; leaves open adenosine mediation of renin inhibition pending further models.
Angiotensin II does not significantly alter circulating plasma adenosine levels in conscious, unrestrained rats, suggesting it does not act via systemic adenosine to inhibit renin release.
Kost et al. (1991) studied Renovascular hypertension. Angiotensin II was evaluated on Plasma adenosine concentrations. Although acute infusion of angiotensin II at 10 ng/min elevated plasma adenosine in anesthetized rats, chronic elevation of angiotensin II did not increase plasma adenosine in conscious, unrestrained rats.
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