Population
Rats (conscious and sodium pentobarbitone anaesthetized)
Comparison
Angiotensin II infusion for 20 min vs Control animals (conscious and anaesthetized)
Design
Preclinical
Follow-up
20 min
Authors
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Robust aldosterone response to angiotensin II occurs in conscious rats but is attenuated by anesthesia; extends experimental design considerations for endocrine research.
The acute aldosterone response to angiotensin II infusion in rats is robust in conscious animals but severely attenuated by anesthesia and surgical preparation.
Coleman et al. (1974) studied this question.
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