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July 1, 1998Hypertension

Differential Regulation of Angiotensin II Receptor Subtypes in the Adrenal Gland

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Why the study?

Does aldosterone alter the expression of AT1 and AT2 receptors in the adrenal gland of rats?

Population

Seven-week-old male Wistar rats (n=28)

Comparison

Aldosterone administered via implanted osmotic… vs Vehicle administered via implanted osmotic…

Design

Preclinical

Follow-up

2 weeks

Authors

DWDonna H. WangMichigan State UniversityJQJingxin QiuRoswell Park Comprehensive Cancer CenterZHZhaoyong HuHunan University of Traditional Chinese Medicine

Discussion

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Implication

Suggests aldosterone autoregulates adrenal receptors in rats; leaves open human relevance and therapeutic implications.

Structured PICO

Does aldosterone alter the expression of AT1 and AT2 receptors in the adrenal gland of rats?

P
Population
Seven-week-old male Wistar rats (n=28)
I
Intervention
Aldosterone (0.05 microg/h) administered via implanted osmotic minipumps for 2 weeks
C
Comparator
Vehicle administered via implanted osmotic minipumps for 2 weeks
O
Outcome
Expression of Ang II receptor subtypes (AT1 and AT2) in the adrenal gland (mRNA levels, receptor density, and location)surrogate

Aldosterone differentially modulates Angiotensin II receptors in the rat adrenal gland by reducing AT2 receptor numbers and altering the location of AT1 receptors.

Cite This Study

Wang et al. (1998) studied this question.

synapsesocial.com/papers/6a8931286fb350aba91279behttps://doi.org/10.1161/01.hyp.32.1.65
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Locally Generated Angiotensin II in the Adrenal Gland Regulates Basal, Corticotropin-, and Potassium-Stimulated Aldosterone Secretion1995 · 62 citations
  2. 2Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor.1994 · 45 citations
  3. 3Mechanisms of enhanced angiotensin II–stimulated signal transduction in vascular smooth muscle by aldosterone1994 · 34 citations
  4. 4Expression of the Subtype 2 Angiotensin (AT<sub>2</sub>) Receptor Protein in Rat Kidney1997 · 319 citations
  5. 5Immunohistochemical localization of rat angiotensin II AT1 receptor1993 · 154 citations