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August 1, 1998Hormone and Metabolic Research

Gene Expression and Roles of Angiotensin II Type 1 and Type 2 Receptors in Human Adrenals

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Key result

In human adrenal tissues, angiotensin II-induced aldosterone secretion was suppressed 50% by an AT1 antagonist, while an AT2 agonist increased secretion by 55% over control.

Population

Human adrenal tissues: normal adrenocortical tissues, aldosterone-producing adrenocortical adenoma…

Comparison

In vitro incubation with angiotensin II with or… vs Control (no antagonist/agonist).

Design

Preclinical

Authors

ATAkiyo TanabeNational Center for Global Health and MedicineMNMitsuhide NarusePreventive CardiologyKAKiyoshi AraiOkayama University of Science

Discussion

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Overview

AT2 receptors may contribute to aldosterone secretion; hypothesis-generating for dual AT1/AT2 targeting, pending clinical studies.

Structured PICO

P
Population
24 human adrenal tissue samples (6 normal, 6 aldosterone-producing adenoma, 6 Cushing's syndrome, 6 pheochromocytoma) evaluated in vitro.
I
Intervention
In vitro incubation with angiotensin II (1 microM) with or without selective AT1 antagonist CV-11974 (1 microM), or selective AT2 agonist CGP-42112.
C
Comparator
Control (no antagonist/agonist).
O
Outcome
Expression of AT1 and AT2 receptor mRNA and aldosterone/cortisol secretion.surrogate

Both AT1 and AT2 receptors are expressed in human adrenal tissues and may be involved in regulating aldosterone secretion and tumorigenesis.

Cite This Study

Tanabe et al. (1998) studied Normal and tumorous human adrenal tissues (n=24). Angiotensin II with or without AT1 antagonist (CV-11974) or AT2 agonist (CGP-42112) vs. Control was evaluated on Aldosterone and cortisol secretion. In human adrenal tissues, angiotensin II-induced aldosterone secretion was suppressed 50% by an AT1 antagonist, while an AT2 agonist increased secretion by 55% over control.

synapsesocial.com/papers/6a690a4e33f858b0ae0cde40https://doi.org/10.1055/s-2007-978918
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proceedings of the Symposium ‘Angiotensin AT<sub>1</sub>Receptors: From Molecular Physiology to Therapeutics’: ANGIOTENSIN II AND THE ADRENAL1996 · 28 citations
  2. 2Expression of type 1 angiotensin II receptors in human aldosteronomas1995 · 19 citations
  3. 3Differential Regulation of Angiotensin II Receptor Subtypes in the Adrenal Gland1998 · 19 citations
  4. 4Angiotensin II receptors: protein and gene structures, expression and potential pathological involvements1996 · 88 citations
  5. 5Distribution and functional significance of angiotensin-II AT1-AND AT2-Receptor subtypes in the rat adrenal gland1998 · 53 citations