Key result
In male Wistar rats, sodium depletion increased adrenal AT1A and AT1B receptor mRNA levels by 60% and 110%, respectively, whereas renovascular hypertension decreased AT1B levels by 50%.
The differential distribution and regulation of AT1A and AT1B receptor subtypes in rat models suggest they mediate different biological effects of Angiotensin II.
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Indicates distinct AT1A/B roles in rat adrenal Ang II regulation; hypothesis-generating, leaves open human hypertension relevance.
Llorens‐Cortés et al. (1994) studied Sodium depletion and renovascular hypertension. Sodium depletion and renovascular hypertension vs. Normal/baseline conditions was evaluated on Adrenal AT1A and AT1B receptor mRNA levels. In male Wistar rats, sodium depletion increased adrenal AT1A and AT1B receptor mRNA levels by 60% and 110%, respectively, whereas renovascular hypertension decreased AT1B levels by 50%.
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