Population
Old compared to adult Long-Evans female rats, pretreated with dexamethasone and captopril and anesthetized…
Comparison
Continuous infusion of angiotensin II for 20 and… vs Adult Long-Evans female rats receiving the same…
Design
Preclinical
Follow-up
30 min
Authors
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Hypothesis-generating for age-related RAAS impairment in rats; leaves open clinical relevance in elderly humans.
Old rats exhibit a significantly diminished aldosterone response to exogenous angiotensin II compared to adult rats, suggesting impaired aldosterone biosynthesis capacity with age.
Rakotondrazafy et al. (2008) studied this question.
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