Key result
Central AngII-induced blood pressure increases and restraint stress-induced elevations were markedly reduced in old rats compared with young rats, while heart rate responses remained similar.
Population
young (5-month-old) and old (27-month-old) male Fischer-344 x Brown-Norway rats
Comparison
Intracerebroventricular infusion of angiotensin… vs Young versus old rats
Design
Preclinical
Follow-up
11 days for angiotensin II infusion, 3 days for losartan…
Authors
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Central AngII BP responses decline with age in rats; leaves open translation to human hypertension mechanisms.
The role of central angiotensin II in regulating blood pressure during baseline and stress conditions diminishes with age in a rat model.
Erdös et al. (2010) studied this question. Intracerebroventricular infusion of AngII vs. Young rats was evaluated on Blood pressure (BP) and heart rate (HR) responses. Central AngII-induced blood pressure increases and restraint stress-induced elevations were markedly reduced in old rats compared with young rats, while heart rate responses remained similar.
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