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December 1, 1985Canadian Journal of Physiology and Pharmacology

Effect of aldosterone on vascular angiotensin II receptors in the rat

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Why the study?

Does aldosterone infusion alter the density and affinity of vascular angiotensin II receptors in rats?

Population

Rats and rat mesenteric artery smooth muscle cells in culture

Comparison

Aldosterone infusion vs Control/baseline states

Design

Preclinical

Follow-up

6 days (in vivo), 18 hours (in vitro)

Authors

ESErnesto L. SchiffrinMedical Council of CanadaDFDouglas J. FranksUniversity of OttawaJGJolanta GutkowskaHeart Failure / Cardiomyopathy

Discussion

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Implication

Hypothesis-generating for aldosterone-angiotensin II receptor crosstalk in rats; leaves open relevance to human hypertension or dual RAAS blockade.

Structured PICO

Does aldosterone infusion alter the density and affinity of vascular angiotensin II receptors in rats?

P
Population
Rats (in vivo mesenteric arteriolar arcades and sodium-depleted models) and rat mesenteric artery smooth muscle cells in culture
I
Intervention
Aldosterone infusion (6.6 micrograms/h intraperitoneally for 6 days in vivo; 3 ng/mL for 18 hours in vitro)
C
Comparator
Control/baseline states (including sodium depletion alone or angiotensin II infusion alone)
O
Outcome
Density and affinity of binding sites for 125I-labelled angiotensin IIsurrogate

Aldosterone up-regulates vascular angiotensin II receptors independently of plasma renin activity, potentially antagonizing the down-regulating action of angiotensin II.

Cite This Study

Schiffrin et al. (1985) studied this question.

synapsesocial.com/papers/6a1ea5d6989adebfe89a6715https://doi.org/10.1139/y85-250
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Prolonged Low Dose Infusion of Angiotensin II and Aldosterone on Rat Smooth Muscle and Adrenal Angiotensin II Receptors*1982 · 46 citations
  2. 2Effect of angiotensin II and deoxycorticosterone infusion on vascular angiotensin II receptors in rats1984 · 86 citations
  3. 3Differential Regulation of Angiotensin II Receptor Subtypes in the Adrenal Gland1998 · 19 citations
  4. 4EFFECT OF ANGIOTENSIN II ON ALDOSTERONE SECRETION IN THE CONSCIOUS RAT1974 · 30 citations
  5. 5Mechanisms of enhanced angiotensin II–stimulated signal transduction in vascular smooth muscle by aldosterone1994 · 34 citations