Key result
Exposure of cultured rat aortic vascular smooth muscle cells to 1 microM aldosterone resulted in a 50-100% enhancement of angiotensin II-stimulated diacylglycerol formation and calcium mobilization.
Population
Cultured rat aortic vascular smooth muscle cells
Comparison
Aldosterone (up to 1 microM) for 24 hours vs Basal conditions or 100 nM 1,25-(OH)2VitD3
Design
Preclinical
Follow-up
24 h
Authors
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May explain sensitized Ang II responses in mineralocorticoid excess; leaves open human vascular relevance.
Aldosterone potentiates angiotensin II-stimulated intracellular signals by increasing the number of AT1 receptors in vascular smooth muscle cells, providing a mechanism for sensitized vascular responses in states of mineralocorticoid excess.
Ullian et al. (1994) studied Cultured rat aortic vascular smooth muscle cells. Aldosterone vs. Basal/unexposed cells was evaluated on Angiotensin II-stimulated diacylglycerol formation and intracellular calcium mobilization. Exposure of cultured rat aortic vascular smooth muscle cells to 1 microM aldosterone resulted in a 50-100% enhancement of angiotensin II-stimulated diacylglycerol formation and calcium mobilization.
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