Population
Cultured rat aortic vascular smooth muscle cells
Comparison
Angiotensin II alone, aldosterone alone, or… vs Control (untreated cells)
Design
Preclinical
Follow-up
up to 72 hours
Authors
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Supports aldosterone-angiotensin II synergy in vascular cells; leaves open translation to human therapy.
Aldosterone upregulates angiotensin II receptors, thereby enhancing angiotensin II-stimulated protein synthesis in vascular smooth muscle cells.
Ullian et al. (1993) studied this question.
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