Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 26, 2006Circulation ResearchOpen Access

The Calcium Paradoxon of Renin Release

View Full Paper
Ask AI
Bookmark
Share

Population

Primary cultures of juxtaglomerular cells, As4.1 cells, and isolated perfused mouse kidneys

Comparison

Calcium-dependent inhibitors of renin release… vs Control conditions

Design

Preclinical

Authors

CGChristian GrünbergerBOBirgit ObermayerJKJürgen Klar

Discussion

Loading...

Member takes

Overview

Clarifies AC5/AC6 mediation of calcium's effect on renin in rodents; hypothesis-generating for human renin-angiotensin regulation.

Structured PICO

P
Population
Primary cultures of juxtaglomerular (JG) cells, As4.1 cells (renin-producing cell line), and isolated perfused mouse kidneys
I
Intervention
Calcium-dependent inhibitors of renin release (angiotensin II, endothelin-1, thapsigargin) and siRNA-mediated knockdown of AC5 and/or AC6
C
Comparator
Control conditions (e.g., membrane permeable cAMP derivates, no siRNA knockdown)
O
Outcome
Renin secretion and intracellular cAMP levelssurrogate

The study demonstrates that the 'calcium paradoxon' of renin release is mediated by the calcium-dependent inhibition of adenylate cyclases AC5 and AC6.

Cite This Study

Grünberger et al. (2006) studied this question.

synapsesocial.com/papers/6a86ace7a6ddb97d43d3b2e3https://doi.org/10.1161/01.res.0000251057.35537.d3
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular mechanism of renin release2004 · 74 citations
  2. 2Aldosterone enhances renin gene expression in juxtaglomerular cells2004 · 40 citations
  3. 3Preserved macula densa-dependent renin secretion in A<sub>1</sub>adenosine receptor knockout mice2003 · 87 citations
  4. 4Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase2000 · 393 citations