Population
Rat renal cortical slice preparation
Comparison
Calcium and calmodulin modulators vs Basal conditions
Design
Preclinical
Authors
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Hypothesis-generating for juxtaglomerular calcium signaling; leaves open translation to human renin regulation and beta-adrenergic independence.
This preclinical study demonstrates that unlike most secretory systems, reducing intracellular calcium or inhibiting the calcium-calmodulin system stimulates renin release from renal juxtaglomerular cells.
Antonipillai et al. (1985) studied this question.
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