Population
Isolated rat glomeruli
Comparison
Calmodulin antagonists (N--5-chloro-naphthalene-1… vs Absence of calmodulin antagonists
Design
Preclinical
Authors
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Calmodulin inhibition of renin release in animal models is hypothesis-generating; leaves open relevance to human hypertension or HF.
The calcium-calmodulin system appears to inhibit renin release, suggesting it is regulated by a mechanism distinct from typical calcium-stimulated exocytosis.
Kawamura et al. (1983) studied this question.
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