Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1992AJP Renal PhysiologyOpen Access

Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro

View Full Paper
Ask AI
Bookmark
Share

Population

Primary cultures of mouse juxtaglomerular (JG) cells

Design

Preclinical

Follow-up

20 h of incubation

Authors

RBRoberto Della BrunaEnte Ospedaliero CantonaleFPF PinetInstitut Pasteur de LillePCPierre CorvolGeneral / Preventive / Lipids

Discussion

Loading...

Member takes

Implication

Calmodulin inhibition may uncouple renin secretion from synthesis in JG cells; leaves open its role in human renin-angiotensin regulation.

Structured PICO

P
Population
Primary cultures of mouse juxtaglomerular (JG) cells
I
Intervention
Calmodulin antagonists (calmidazolium [CMDZ], N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide [W-7], and trifluoperazine [TFP]) and cycloheximide
O
Outcome
Renin secretion and de novo synthesis of reninsurrogate

Inhibition of calmodulin activity stimulates renin exocytosis but inhibits renin and total protein synthesis in mouse juxtaglomerular cells, suggesting calmodulin does not positively link renin synthesis and secretion.

Cite This Study

Bruna et al. (1992) studied this question.

synapsesocial.com/papers/6a86ac893f44447e627cab61https://doi.org/10.1152/ajprenal.1992.262.3.f397
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of Renin Secretion and Renin Synthesis by Second Messengers in Isolated Mouse Juxtaglomerular Cells1991 · 50 citations
  2. 2Nonproportional changes in plasma renin concentration, renal renin content, and rat renin messenger RNA.1985 · 82 citations
  3. 3Modulation of kidney renin messenger RNA levels during experimentally induced hypertension.1986 · 51 citations
  4. 4A RELEASE OF RENIN FROM DOG KIDNEY CORTEX SLICES1970 · 44 citations
  5. 5Molecular biology of the renin-angiotensin system1988 · 154 citations