July 1, 1996AJP Cell Physiology

Inhibition of renin secretion by Ca2+ through activation of myosin light chain kinase

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Population

Rat renal cortical slices

Comparison

Inhibitors of protein kinase and phosphatases in… vs K+-rich depolarizing medium alone

Design

Preclinical

Authors

CPC. S. ParkSungkyunkwan University SCS.-H. ChangChang Gung University HLH. S. LeeAsan Medical Center

Discussion

Member takes

Implication

MLCK inhibition may preserve renin secretion in animal JG cells; leaves open therapeutic relevance for human hypertension.

Structured PICO

Population

Rat renal cortical slices

Intervention

Inhibitors of protein kinase and phosphatases (including MLCK inhibitors ML-9, ML-7, KT-5926, and wortmannin) in K+-rich depolarizing medium

Comparator

K+-rich depolarizing medium alone

Outcome

Inhibition of renin secretionsurrogate

This study provides evidence that activation of Ca2+-calmodulin-dependent myosin light chain kinase plays an important role in the inhibitory stimulus-secretion coupling of renin in juxtaglomerular cells.

Cite This Study

Park et al. (1996) studied this question.

synapsesocial.com/papers/6a86ad80241d06231dbee87c https://doi.org/10.1152/ajpcell.1996.271.1.c242

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Inhibition of renin secretion by Ca2+ through activation of myosin light chain kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of renin secretion by Ca2+ through activation of myosin light chain kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider