Population
Rabbit renal cortical slices
Comparison
Nigericin or benzylamine in Ca2+-free incubation… vs Ca2+-free medium vs Ca2+-containing medium
Design
Preclinical
Authors
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Does not support clinical use of calmodulin modulators for renin control; leaves open mechanistic validation in vivo.
Ca2+ acting through calmodulin may inhibit renin secretion by blocking an early step such as pH gradient-dependent swelling of renin secretory granules.
Park et al. (1992) studied this question.
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