September 1, 1986AJP Regulatory Integrative and Comparative Physiology

Control of renin secretion by Ca2+ and cyclic AMP through two parallel mechanisms

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Population

Rabbit renal cortical slices

Comparison

Forskolin at varying concentrations, with or… vs Varying concentrations of forskolin and…

Design

Preclinical

Authors

CPC. S. Park DSDavid H. SigmonTulane University DHDan HanAnhui Medical University

Discussion

Member takes

Implication

Does not inform clinical renin management; leaves open independent cAMP-Ca2+ signaling in juxtaglomerular cells for further mechanistic study.

Structured PICO

Population

Rabbit renal cortical slices

Intervention

Forskolin (adenyl cyclase stimulator) at varying concentrations, with or without high-K+ depolarizing medium or calmodulin antagonists

Comparator

Varying concentrations of forskolin and intracellular Ca2+

Outcome

Renin secretion in vitrosurrogate

This preclinical study demonstrates that cAMP stimulates renin secretion through a cellular mechanism independent of the inhibitory Ca2+-calmodulin pathway.

Cite This Study

Park et al. (1986) studied this question.

synapsesocial.com/papers/6a8930a303fab2a419a5f79b https://doi.org/10.1152/ajpregu.1986.251.3.r531

View Full Paper

Ask AI

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Implication

Does not inform clinical renin management; leaves open independent cAMP-Ca2+ signaling in juxtaglomerular cells for further mechanistic study.

Control of renin secretion by Ca2+ and cyclic AMP through two parallel mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Control of renin secretion by Ca2+ and cyclic AMP through two parallel mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider