Population
Rat renal cortical slices
Comparison
Ca2+ addition to media producing osmotic… vs Media without Ca2+ or without ML-9
Design
Preclinical
Authors
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MLCK mediates Ca2+ inhibition of swelling-stimulated renin secretion; extends mechanistic insights in animals but leaves open human relevance.
The inhibitory effect of Ca2+ on renin secretion stimulated by osmotic swelling is mediated by myosin light chain kinase (MLCK).
Park et al. (1996) studied this question.
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