Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1988Journal of Cardiovascular PharmacologyOpen Access

Rat Juxtaglomerular Cells are Endowed with DA-1 Dopamine Receptors Mediating Renin Release

View Full Paper
Ask AI
Bookmark
Share

Population

Primary culture containing about 80-90% of granular juxtaglomerular cells prepared from rat kidneys, and…

Comparison

Dopamine, fenoldopam, and isoproterenol, with or… vs Control conditions

Design

Preclinical

Authors

AKA. KurtzUniversity of BernRBRoberto Delia BrunaUniversity of ZurichJPJ. PratzSmiths Detection (France)

Discussion

Loading...

Member takes

Implication

Should not change clinical renin-angiotensin management; leaves open DA-1 receptor targeting in human cardiorenal disease.

Structured PICO

P
Population
Primary culture containing about 80-90% of granular juxtaglomerular (JG) cells prepared from rat kidneys, and pithed rats
I
Intervention
Dopamine, fenoldopam (DA-1 agonist), and isoproterenol, with or without antagonists (SCH 23390, S-sulpiride, phentolamine, propranolol)
C
Comparator
Control conditions
O
Outcome
Renin secretion (in vitro) and plasma renin activity (in vivo)surrogate

DA-1 dopamine receptors are present on rat kidney juxtaglomerular cells and mediate renin secretion upon pharmacological stimulation.

Cite This Study

Kurtz et al. (1988) studied this question.

synapsesocial.com/papers/6a7d67b17786afdcaca015c9https://doi.org/10.1097/00005344-198812000-00006
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dopamine D<sub>1A</sub>Receptors and Renin Release in Rat Juxtaglomerular Cells1997 · 59 citations
  2. 2Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release.1989 · 35 citations
  3. 3The Effects of Dopamine on Renin Release<i>in Vitro</i>1977 · 22 citations
  4. 4Dopamine D<sub>3</sub>Receptors in Rat Juxtaglomerular Cells1997 · 51 citations
  5. 5Role of Nitric Oxide in the Control of Renin Release from the Normal and Hydronephrotic Rat Kidney1994 · 7 citations