April 1, 1997Hypertension

Dopamine D1AReceptors and Renin Release in Rat Juxtaglomerular Cells

View Full Paper

Ask AI

Bookmark

Population

Rat juxtaglomerular cells obtained after enzymatic dispersion of kidney cortex and differential…

Comparison

Dopamine, fenoldopam, SCH23390, and antisense… vs Sense D1A oligonucleotides or control conditions

Design

Preclinical

Authors

IYIkuyo YamaguchiChildren's Hospital of Oklahoma LYLynne YaoUnited States Food and Drug Administration HSHironobu SanadaUniversity of Maryland, Baltimore

Discussion

Member takes

Implication

D1A mediates renin secretion in rat JG cells; hypothesis-generating for human hypertension pathways and leaves open clinical translation.

Structured PICO

Population

Rat juxtaglomerular cells obtained after enzymatic dispersion of kidney cortex and differential centrifugation (85% to 95% renin positive in primary culture).

Intervention

Dopamine, fenoldopam (D1-like receptor agonist), SCH23390 (D1-like receptor antagonist), and antisense D1A oligonucleotides

Comparator

Sense D1A oligonucleotides or control conditions

Outcome

cAMP production and renin secretionsurrogate

The dopamine receptor subtype linked to the stimulation of cAMP and renin secretion in rat juxtaglomerular cells is the D1A subtype.

Cite This Study

Yamaguchi et al. (1997) studied this question.

synapsesocial.com/papers/6a7d67b17786afdcaca015bc https://doi.org/10.1161/01.hyp.29.4.962

View Full Paper

Ask AI

Bookmark

Dopamine D1AReceptors and Renin Release in Rat Juxtaglomerular Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dopamine D1AReceptors and Renin Release in Rat Juxtaglomerular Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider