Population
Rats on a high-sodium intake
Comparison
Direct renal interstitial infusion of… vs Vehicle infusion
Design
Preclinical
Follow-up
Three 1-hour experimental periods
Authors
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D1-AT2 receptor crosstalk may mediate natriuresis in animal models; hypothesis-generating and should not yet change practice.
Dopamine D1-like receptor stimulation induces natriuresis via recruitment and activation of AT2 receptors in the renal proximal tubules.
Salomone et al. (2006) studied this question.
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