January 1, 1987Clinical and Experimental Hypertension
Selective Renal Dopamine-1 Receptor Stimulation in Man
Why the study?
Does intravenous fenoldopam induce natriuresis and alter renal hemodynamics in normal male subjects?
Population
10 normal male subjects on a diet of 150 mEq sodium and 60 mEq potassium per day
Comparison
Fenoldopam (intravenous administration) vs Baseline (control) measurements
Design
Other
Authors
Discussion
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Member takes
Implication
Supports DA-1 agonism as a probe for renal hemodynamics in humans; leaves open translation to patients with hypertension or heart failure.
Structured PICO
Does intravenous fenoldopam induce natriuresis and alter renal hemodynamics in normal male subjects?
P
Population
10 normal male subjects on a diet of 150 mEq sodium and 60 mEq potassium per day
I
Intervention
Fenoldopam (intravenous administration)
C
Comparator
Baseline (control) measurements
O
Outcome
Urine flow rate, renal plasma flow, sodium excretion (UNaV), fractional sodium excretion (FENa), and glomerular filtration ratesurrogate
Intravenous fenoldopam causes natriuresis through direct renal tubular action and increases renal plasma flow without changing glomerular filtration rate in normal men.
Cite This Study
Carey et al. (1987) studied this question.