Why the study?
Does a single oral dose of fenoldopam affect blood pressure and renal function in healthy male subjects?
Population
7 healthy male subjects
Comparison
Single oral dose of 100 mg of fenoldopam vs Placebo
Design
RCT, double-blind
Follow-up
210 minutes
Authors
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Supports oral fenoldopam development for renal indications; extends prior IV DA1 agonist data to healthy subjects.
Does a single oral dose of fenoldopam affect blood pressure and renal function in healthy male subjects?
A single oral dose of fenoldopam produces a pronounced renal vasodilator effect lasting about 2 hours and transiently lowers diastolic blood pressure in healthy men.
Harvey et al. (1985) studied this question.
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