Population
Rat isolated perfused kidney model
Comparison
Dopexamine and fenoldopam (bolus doses) vs SCH 23390 and prazosin
Design
Preclinical
Authors
Loading...
Challenges presumed D1 mediation of dopexamine/fenoldopam renal vasodilation in rats; leaves open relevance to human physiology or therapy.
Dopexamine and fenoldopam induce renal vasodilatation via alpha-1 adrenoceptor blockade rather than direct D1-receptor activation in the rat isolated perfused kidney model.
Martin et al. (1995) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: