Why the study?
Does fenoldopam alter the expression and interaction of D1 and AT1 receptors differently in renal proximal tubule cells from spontaneously hypertensive rats compared to normotensive rats?
Population
Immortalized renal proximal tubule cells from spontaneously hypertensive rats and normotensive Wistar-Kyoto…
Comparison
Fenoldopam 10 mol/L per 24 hours vs Untreated cells and cells treated with SCH 23390
Design
Preclinical
Follow-up
24 hours
Authors
Loading...
Differential D1-AT1 receptor interactions in hypertensive rat cells; leaves open human relevance and therapeutic targeting.
Does fenoldopam alter the expression and interaction of D1 and AT1 receptors differently in renal proximal tubule cells from spontaneously hypertensive rats compared to normotensive rats?
Altered interaction and differential regulation of D1 and AT1 receptors in spontaneously hypertensive rats may contribute to the pathogenesis of hypertension.
Zeng et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: