Key result
Fenoldopam-induced natriuresis requires AT2R recruitment to the apical plasma membranes of renal proximal tubule cells via a microtubule-dependent adenylyl cyclase/cAMP signaling pathway.
D1R-induced natriuresis requires AT2R recruitment to the apical plasma membranes of renal proximal tubule cells in a microtubule-dependent manner involving an adenylyl cyclase/cAMP signaling pathway.
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Hypothesis-generating for AT2R recruitment in renal sodium handling; human studies needed before therapeutic consideration.
Padia et al. (2011) studied this question. Fenoldopam vs. PD-123319 or nocodazole was evaluated on Natriuretic response and AT2R translocation. Fenoldopam-induced natriuresis requires AT2R recruitment to the apical plasma membranes of renal proximal tubule cells via a microtubule-dependent adenylyl cyclase/cAMP signaling pathway.
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