Key result
Exposure of rat renal proximal tubule cells to a D1 agonist or angiotensin II resulted in rapid partial internalization and complete abolishment of signaling of the reciprocal receptor.
Population
Rat renal proximal tubule cells and renal tissue
Design
Preclinical
Authors
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May inform renal sodium regulation mechanisms in rats; leaves open translation to human hypertension or diuretic responses.
AT1R and D1R form a multiprotein complex with Na+-K+-ATPase and exhibit negative reciprocity, providing a mechanism for the precise short-term regulation of sodium excretion.
Khan et al. (2008) studied this question. D1 agonist and Angiotensin II was evaluated on Receptor internalization and signaling abolishment. Exposure of rat renal proximal tubule cells to a D1 agonist or angiotensin II resulted in rapid partial internalization and complete abolishment of signaling of the reciprocal receptor.
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