Why the study?
Although renal D1R and AT2R activation regulates renal sodium transport and blood pressure, little is known regarding the precise mechanism of this interaction.
Identifies a reciprocal transregulation mechanism between D1R and AT2R via PKA, PKG, and PP2A pathways that regulates sodium transport in renal cells.
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Identifies a renal sodium transport mechanism in animals; leaves open translation to human hypertension therapies.
Gildea et al. (2019) studied this question.
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