January 1, 1997Clinical and Experimental Hypertension

Dopamine D3Receptors in Rat Juxtaglomerular Cells

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Population

Primary cultures of rat juxtaglomerular (JG) cells (n=3 for RT-PCR, n=3-7/group for cAMP assay)

Comparison

LY-171555 and PD-128593 vs YM-09151 (non-selective D2-like antagonist)

Design

Preclinical

Authors

HSHironobu SanadaUniversity of Maryland, Baltimore LYLynne YaoUnited States Food and Drug Administration PJPedro A. JoséGeneral / Preventive / Lipids

Discussion

Member takes

Implication

D3/D4 receptors may inhibit cAMP in rat JG cells; extends renal dopamine mapping but leaves open human renin regulation.

Structured PICO

Population

Primary cultures of rat juxtaglomerular (JG) cells (n=3 for RT-PCR, n=3-7/group for cAMP assay)

Intervention

LY-171555 (non-selective D2-like receptor agonist) and PD-128593 (partially selective D3 agonist)

Comparator

YM-09151 (non-selective D2-like antagonist)

Outcome

Identification of D2-like receptor subtypes (mRNA) and inhibition of forskolin-stimulated cAMP productionsurrogate

D3 and D4 dopamine receptor subtypes are expressed in rat juxtaglomerular cells and are linked to the inhibition of cAMP production.

Cite This Study

Sanada et al. (1997) studied this question.

synapsesocial.com/papers/6a7d67b17786afdcaca015be https://doi.org/10.3109/10641969709080807

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January 1, 1997Clinical and Experimental Hypertension

Dopamine D3Receptors in Rat Juxtaglomerular Cells

View Full Paper

Ask AI

Bookmark

Population

Primary cultures of rat juxtaglomerular (JG) cells (n=3 for RT-PCR, n=3-7/group for cAMP assay)

Comparison

LY-171555 and PD-128593 vs YM-09151 (non-selective D2-like antagonist)

Design

Preclinical

Authors

HSHironobu SanadaUniversity of Maryland, Baltimore LYLynne YaoUnited States Food and Drug Administration PJPedro A. JoséGeneral / Preventive / Lipids

Discussion

Member takes

Implication

D3/D4 receptors may inhibit cAMP in rat JG cells; extends renal dopamine mapping but leaves open human renin regulation.

Structured PICO

Population

Primary cultures of rat juxtaglomerular (JG) cells (n=3 for RT-PCR, n=3-7/group for cAMP assay)

Intervention

LY-171555 (non-selective D2-like receptor agonist) and PD-128593 (partially selective D3 agonist)

Comparator

YM-09151 (non-selective D2-like antagonist)

Outcome

Identification of D2-like receptor subtypes (mRNA) and inhibition of forskolin-stimulated cAMP productionsurrogate

D3 and D4 dopamine receptor subtypes are expressed in rat juxtaglomerular cells and are linked to the inhibition of cAMP production.

Cite This Study

Sanada et al. (1997) studied this question.

synapsesocial.com/papers/6a7d67b17786afdcaca015be https://doi.org/10.3109/10641969709080807

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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