What question did this study set out to answer?

To review the physiological actions of renal dopamine receptor subtypes and delineate their role in the pathogenesis of essential hypertension.

Renal Dopamine Receptors in Health and Hypertension

View Full Paper

Ask AI

Bookmark

Design

Review

Authors

May implicate renal dopamine dysfunction in hypertension; leaves open whether receptor modulation improves outcomes.

To review the physiological actions of renal dopamine receptor subtypes and delineate their role in the pathogenesis of essential hypertension.
Review of pharmacological, molecular cloning, and expression profiling studies of D1-like and D2-like dopamine receptors across nephron segments.
Analysis of transgenic mouse models lacking specific dopamine receptors and clinical investigations of sodium excretion in hypertensive humans.
Dopamine produced locally in proximal tubules acts via D1-like and D2-like receptors to regulate hemodynamics, electrolyte and water transport, and renin secretion during extracellular volume expansion.
Genetic disruption of D1 or D3 receptors produces hypertension in mice, paralleling the defective dopamine production seen in humans with essential hypertension challenged by sodium loading.
Renal dopaminergic pathway failure in hypertension likely involves post-translational modifications of the receptors rather than simple loss of expression.

José et al. (1998) studied this question.

View Full Paper

Ask AI

Bookmark