May 1, 1989HypertensionOpen Access

Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release.

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Why the study?

Does dopamine stimulate renin release via specific dopamine-1 receptor activation in rat renal cortical slices?

Population

Rat renal cortical slices

Comparison

Dopamine (10M) and specific dopamine-1 and… vs Control (untreated slices)

Design

Preclinical

Authors

IAI. AntonipillaiUniversity of Southern California MBM I BroersLAC+USC Medical Center DLD. LangCanadian Light Source (Canada)

Discussion

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Implication

D1-mediated renin stimulation in rat kidney slices; hypothesis-generating and leaves open any role in human hypertension.

Structured PICO

Does dopamine stimulate renin release via specific dopamine-1 receptor activation in rat renal cortical slices?

Population

Rat renal cortical slices

Intervention

Dopamine (10(-5)M) and specific dopamine-1 and dopamine-2 receptor agonists/antagonists (fenoldopam, quinpirole, SCH 23390, pimozide)

Comparator

Control (untreated slices)

Outcome

Renin releasesurrogate

Dopamine directly stimulates renin secretion in the kidney through specific dopamine-1 receptor activation.

Cite This Study

Antonipillai et al. (1989) studied this question.

synapsesocial.com/papers/6a7d67b17786afdcaca015c8 https://doi.org/10.1161/01.hyp.13.5.463

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Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider