Population
Anesthetized dogs (including intact, ganglion-blocked, and uninephrectomized preparations)
Comparison
Fenoldopam vs Baseline and co-administration with antagonists
Design
Preclinical
Follow-up
15 minutes
Authors
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May explain fenoldopam tolerance in animals; leaves open relevance to human DA1 pharmacology and hypotension management.
Fenoldopam directly stimulates dopamine-1 (DA1) receptors on juxtaglomerular cells to increase plasma renin activity, which mediates tolerance to its hypotensive effects.
Montier et al. (1989) studied this question.
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