Key result
Fenoldopam plus dobutamine boosts cardiac contractile force over dopamine while matching renal blood flow gains.
Why the study?
The cardiovascular and renal hemodynamic effects of intravenous fenoldopam alone or combined with dopamine and dobutamine were not fully characterized.
Does intravenous fenoldopam alone or combined with dopamine or dobutamine improve renal blood flow and hemodynamics in anesthetized dogs?
Population
Pentobarbital-anesthetized dogs
Comparison
Fenoldopam alone or with dopamine and dobutamine vs dopamine and dobutamine alone
Design
Preclinical experimental study
Authors
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Animal data warrant clinical caution; leaves open translation of fenoldopam-dobutamine synergy to human hemodynamics.
Does intravenous fenoldopam alone or combined with dopamine or dobutamine improve renal blood flow and hemodynamics in anesthetized dogs?
In an animal model, combining fenoldopam with dobutamine provides superior cardiac contractile force and equivalent renal blood flow increases compared to dopamine alone.
Lass et al. (1988) studied this question. Fenoldopam vs. Dopamine and dobutamine was evaluated on Renal blood flow, heart rate, and mean arterial pressure. Fenoldopam combined with dobutamine produced greater increments in cardiac contractile force than dopamine and equivalent increases in renal blood flow as dopamine in anesthetized dogs.
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