Why the study?
Does fenoldopam dose-dependently increase renal sodium excretion and alter hemodynamics in anesthetized dogs?
Population
Pentobarbital-anesthetized dogs divided into four separate groups
Comparison
Fenoldopam infusion for 30 min at doses of… vs DA-1 receptor antagonist SCH 23390
Design
Preclinical
Follow-up
30 min infusion and two 30 min recovery periods
Authors
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Animal findings support low-dose fenoldopam exploration for natriuresis; leaves open translation to human cardiorenal trials.
Does fenoldopam dose-dependently increase renal sodium excretion and alter hemodynamics in anesthetized dogs?
Fenoldopam induces natriuresis and diuresis at low doses without significant hemodynamic effects, while higher doses cause hypotension that may blunt the renal excretory response.
Dlewati et al. (1991) studied this question.
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