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January 1, 1994Endothelium

Role of Nitric Oxide in the Control of Renin Release from the Normal and Hydronephrotic Rat Kidney

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Population

Isolated perfused normal and hydronephrotic rat kidneys

Comparison

Inhibitors or stimulators of endothelium-derived… vs Basal state or absence of specific…

Design

Preclinical

Authors

EHE. HackenthalHeidelberg UniversityKMKlaus MünterBayer (Germany)SFSamuel FritschMontana State University

Discussion

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Implication

Indicates nitric oxide may stimulate renin release in animals; leaves open translation to human renin-angiotensin regulation.

Structured PICO

P
Population
Isolated perfused normal and hydronephrotic rat kidneys
I
Intervention
Inhibitors or stimulators of endothelium-derived relaxing factor (EDRF) and nitric oxide-generating drugs (acetylcholine, carbachol, L-NNA, L-NMMA, L-arginine, SIN-1, L-NAME, sodium nitroprusside)
C
Comparator
Basal state or absence of specific inhibitors/stimulators
O
Outcome
Renin release/secretionsurrogate

Endothelium-derived relaxing factor (nitric oxide) acts as a direct stimulator of renin release from juxtaglomerular cells.

Cite This Study

Hackenthal et al. (1994) studied this question.

synapsesocial.com/papers/6a83fa33f72f0ca72062d39ahttps://doi.org/10.3109/10623329409053380
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney.1993 · 91 citations
  2. 2Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat1990 · 41 citations
  3. 3Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells.1991 · 57 citations
  4. 4The effects of endothelin on renovascular resistance and renin release1989 · 19 citations
  5. 5Nitric oxide synthase in macula densa regulates glomerular capillary pressure.1992 · 529 citations