March 1, 1993Journal of Clinical InvestigationOpen Access

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney.

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Population

Isolated rat kidneys perfused at controlled pressure

Comparison

Stimulation of EDRF release by acetylcholine… vs Control conditions

Design

Preclinical

Authors

HSHolger C. ScholzRobert Koch Institute AKArmin KurtzShanghai CASB Biotechnology (China)

Discussion

Member takes

Implication

EDRF may mediate pressure-dependent renin release in kidneys; hypothesis-generating and should not change clinical practice.

Structured PICO

Population

Isolated rat kidneys perfused at controlled pressure

Intervention

Stimulation of EDRF release by acetylcholine (1 mumol/liter), inhibition of EDRF formation with NG-nitro-L-arginine (100 mumol/liter), addition of sodium nitroprusside (10 mumol/liter), and lowering of perfusion pressure from 100 mmHg to 40 mmHg

Comparator

Control conditions (baseline perfusion pressure of 100 mmHg without EDRF modulators)

Outcome

Renin secretion rates (ng angiotensin I/h per min per g) and mean perfusate flow rates (ml/min per g)surrogate

EDRF and related activators of soluble guanylate cyclase stimulate renin secretion from isolated kidneys, suggesting that pressure control of renin secretion requires tonic stimulation by intrarenal EDRF.

Cite This Study

Scholz et al. (1993) studied this question.

synapsesocial.com/papers/6a81f4e1ac3bbfe76d610150 https://doi.org/10.1172/jci116266

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Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider