Population
Preclinical model undergoing experimental manipulation of renal perfusion
Comparison
Alteration of mean renal perfusion pressure vs Baseline/control levels of perfusion pressure
Design
Preclinical
Key result
Reducing mean renal perfusion pressure by 5 to 40 mm Hg increased renin secretion within 60 seconds independently of renal blood flow, suggesting regulation by a renal baroreceptor mechanism.
Authors
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Hypothesis-generating for renal baroreceptor in renin control; leaves open human translation and clinical relevance.
Demonstrates that renin secretion is controlled by a renal baroreceptor mechanism responding to mean perfusion pressure rather than ischemia.
Skinner et al. (1964) studied Renin secretion regulation. Reduction of mean renal perfusion pressure vs. Control levels / Rises in perfusion pressure was evaluated on Rate of renin secretion. Reducing mean renal perfusion pressure by 5 to 40 mm Hg increased renin secretion within 60 seconds independently of renal blood flow, suggesting regulation by a renal baroreceptor mechanism.