What question did this study set out to answer?

To determine whether renin release elicited by reduced renal arterial pressure is enhanced by beta-adrenergic stimulation or suppressed by beta-blockade.

January 1, 1974Scandinavian Journal of Clinical and Laboratory Investigation

Potentiation of Renin Release by Combining Renal Arterial Constriction and β -Adrenergic Stimulation

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Why the study?

Does beta-adrenergic stimulation or blockade affect renin release differently at low versus normal renal arterial pressure in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Isoproterenol or propranolol administered via… vs Control renal arterial pressure vs low renal…

Design

Preclinical

Authors

IEIvar EideOslo University Hospital ELE. LöyningUniversity of Oslo FKFredrik KiilOslo University Hospital

Discussion

Member takes

Implication

Pressure-dependent beta-adrenergic renin effects in dogs; hypothesis-generating and should not yet change clinical practice.

Key Points

To determine whether renin release elicited by reduced renal arterial pressure is enhanced by beta-adrenergic stimulation or suppressed by beta-blockade.
Assessed renin release in anesthetized dogs at control renal arterial pressure (120–140 mm Hg) and constricted low pressure (50–60 mm Hg).
Administered the beta-agonist isoproterenol (0.2 μg/min per kg intra-arterially and intravenously) or the beta-antagonist propranolol under both pressure conditions.
Isoproterenol raised renin release significantly more at low pressure (from 31.9 ± 3.2 to 54.3 ± 5.0 μg/min; ΔRR = 22.4 ± 2.9 μg/min) than at control pressure (from 1.8 ± 0.5 to 8.9 ± 1.7 μg/min; ΔRR = 7.1 ± 1.6 μg/min; P < 0.05).
Propranolol suppressed renin release to a greater degree at low arterial pressure (from 43.8 ± 10.9 to 27.9 ± 4.2 μg/min; ΔRR = −15.9 ± 8.3 μg/min) than at control pressure (from 2.1 ± 0.8 to 0.5 ± 0.4 μg/min; ΔRR = −1.6 ± 0.8 μg/min; P < 0.05).

Structured PICO

Does beta-adrenergic stimulation or blockade affect renin release differently at low versus normal renal arterial pressure in anesthetized dogs?

Population

Anesthetized dogs

Intervention

Isoproterenol (0.2 μg/min per kg body weight) or propranolol administered via intrarenal or intravenous infusion at control pressure (120-140 mm Hg) and after constricting the renal artery to a low pressure (50-60 mm Hg)

Comparator

Control renal arterial pressure (120-140 mm Hg) vs low renal arterial pressure (50-60 mm Hg)

Outcome

Renin releasesurrogate

The combination of low renal arterial pressure and high sympathetic beta-receptor activity potentiates renin release in a canine model.

Cite This Study

Eide et al. (1974) studied this question.

synapsesocial.com/papers/6a8a41fc273d243e4992f75f https://doi.org/10.3109/00365517409049884

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Potentiation of Renin Release by Combining Renal Arterial Constriction and β -Adrenergic Stimulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Potentiation of Renin Release by Combining Renal Arterial Constriction and β -Adrenergic Stimulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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