What does this research mean for the field?

The stimulation of renin secretion by renal nerve stimulation is mediated by intrarenal beta-adrenergic receptors, as the response is abolished by beta-adrenergic blockade but not by local anesthetic activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether intrarenal beta-adrenergic receptors mediate renin release stimulated by direct renal nerve stimulation, independently of local anesthetic drug properties.

February 1, 1976Journal of Clinical InvestigationOpen Access

Effect of beta adrenergic blockade on renin response to renal nerve stimulation.

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Why the study?

Does beta-adrenergic blockade prevent renin secretion in response to renal nerve stimulation in dogs?

Population

Dogs (animal model)

Comparison

dl-propranolol, l-propranolol, or d-propranolol… vs Control group receiving sequential RNS without…

Design

Preclinical

Authors

MTMahboobe TaherIslamic Azad University, Shahrood LMLarry G. McLainLoyola University Medical Center KMK. M. McDonaldUniversity of Vermont

Discussion

Member takes

Implication

Hypothesis-generating for intrarenal beta-adrenergic renin control in dogs; leaves open human translation and clinical relevance.

Key Points

To determine whether intrarenal beta-adrenergic receptors mediate renin release stimulated by direct renal nerve stimulation, independently of local anesthetic drug properties.
Assessed renin secretion in canine models undergoing electrical renal nerve stimulation (RNS) across four experimental groups.
Administered different propranolol isomers to distinguish pharmacological mechanisms: dl-propranolol (beta-blocker and anesthetic), l-propranolol (beta-blocker only), and d-propranolol (anesthetic only), alongside untreated controls.
In control animals, sequential RNS increased mean renin secretion from 401 to 1,255 U/min (P < 0.25) and from 220 to 2,179 U/min (P < 0.01).
Administration of dl-propranolol and l-propranolol completely blocked the renin response to RNS (post-treatment RNS: 33 to 55 U/min and 84 to 51 U/min, respectively).
Pretreatment with d-propranolol failed to block renin secretion, which rose from 80 to 482 U/min (P < 0.005) during stimulation without altering renal hemodynamics.

Structured PICO

Does beta-adrenergic blockade prevent renin secretion in response to renal nerve stimulation in dogs?

Population

Dogs (animal model)

Intervention

dl-propranolol, l-propranolol, or d-propranolol administered prior to renal nerve stimulation (RNS)

Comparator

Control group receiving sequential RNS without beta-blockade, and baseline RNS response prior to drug administration

Outcome

Renin secretion rate (U/min)surrogate

Beta-adrenergic blockade specifically inhibits renin secretion in response to renal nerve stimulation, supporting the existence of an intrarenal beta receptor that regulates renin release.

Cite This Study

Taher et al. (1976) studied this question.

synapsesocial.com/papers/6a18d775b6950308983083cb https://doi.org/10.1172/jci108297

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Effect of beta adrenergic blockade on renin response to renal nerve stimulation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of beta adrenergic blockade on renin response to renal nerve stimulation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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