Population
6 conscious resting uninephrectomized dogs with chronically indwelling catheters in the aorta, vena cava…
Comparison
Propranolol infusion directly into the renal… vs Intravenous propranolol infusion at the same…
Design
Preclinical
Follow-up
45 min
Authors
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Supports renal beta-blockade as mechanism of propranolol's PRA suppression in dogs; leaves open human translation.
Suppression of plasma renin activity by propranolol is due solely to blockade of renal beta-adrenergic receptors in conscious sodium-deprived dogs.
Blair et al. (1995) studied this question.
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