Why the study?
Does nitric oxide synthesis blockade with L-NAME alter renin release in rats under varying renal perfusion pressures?
Population
Rats (including a series with bilateral renal denervation)
Comparison
NG-nitro-L-arginine methyl ester administration… vs Control rats not receiving L-NAME
Design
Preclinical
Authors
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NO not strictly required for pressure-sensing renin release in rats; leaves open paracrine role for translational studies.
Does nitric oxide synthesis blockade with L-NAME alter renin release in rats under varying renal perfusion pressures?
Nitric oxide synthesis is not stringently required for the intrarenal pressure-sensing mechanism of renin release, but NO may act as a paracrine stimulator.
Johnson et al. (1994) studied this question.
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