Population
Kidneys of various species and hydronephrotic kidney preparation of the mouse
Comparison
Noradrenaline, angiotensin II, and isoproterenol vs Baseline / plain smooth-muscle cells
Design
Preclinical
Authors
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Indicates beta1-mediated renin release may bypass depolarization; hypothesis-generating for juxtaglomerular signaling in vivo.
Stimulus-secretion coupling for renin via the beta 1-adrenoreceptor likely proceeds without changes in membrane potential in granulated cells.
Bührle et al. (1984) studied this question.
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