In cultured rat adrenal zona glomerulosa cells, various trophic stimuli initially stimulate aldosterone biosynthesis but fail to maintain it indefinitely, while ACTH induces a shift toward fasciculata-reticularis-like functional and morphological characteristics.
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In vitro K+ effects on aldosterone should not inform clinical practice; leaves open mechanisms sustaining zona glomerulosa function in vivo.
Hornsby et al. (1974) studied this question.
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