Population
Long Evans rats
Comparison
ACTH 15 IU/day for 1-9 days vs Control rats
Design
Preclinical
Follow-up
up to 19 days post-treatment
Authors
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Hypothesis-generating for ACTH effects on adrenal AII receptors; leaves open translation to human aldosterone disorders.
Chronic ACTH treatment in rats induces a reversible loss of angiotensin II receptors and decreases the in vitro steroidogenic responsiveness of adrenal zona glomerulosa cells.
Legros et al. (1983) studied this question.
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