Key result
In the rat, ACTH directly stimulated a rise in plasma renin activity, an effect that was completely inhibited by glucocorticoid pretreatment.
No immediate clinical implications; leaves open ACTH-renin interactions in humans.
SummaryIn the rat, ACTH effected a transient rise in the level of plasma renin. Pretreatment with glucocorticoids completely inhibited the ACTH-induced renin rise. After adrenalectomy or inhibition of steroidogenesis by aminoglutethimide. ACTH produced a sustained rise in plasma renin level. Thus in the rat, ACTH has a direct effect on the juxtaglomerular apparatus causing a rise in plasma renin activity and glucocorticoids have an opposing action.
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Hauger-Klevene et al. (1969) studied this question. ACTH vs. Glucocorticoid pretreatment, adrenalectomy, or aminoglutethimide was evaluated on Plasma renin level. In the rat, ACTH directly stimulated a rise in plasma renin activity, an effect that was completely inhibited by glucocorticoid pretreatment.