Sympathetic stimulation and catecholamine administration in dogs induce transient electrocardiographic patterns of coronary insufficiency associated with increased cardiac efficiency.
Requires caution interpreting transient ECG changes during sympathetic surges; leaves open human translation of canine findings.
In order to investigate the pathologic physiology of coronary insufficiency of neurohormonal origin, the experimental studies were carried out on dogs. The relationships among cardiac work, cardiac oxygen uptake, cardiac mechanical efficiency and electrocardiograms, and the effects of administrations of adrenaline and noradrenaline and of electrical stimulations of the cervical and spinal sympathetic nerves, were studied. In an early stage of all experiments, the electrocardiogram showed a coronary insufficiency pattern in accordance with increase in cardiac efficiency. In many cases, this insufficiency pattern disappeared with restoration of the original state or decrease in cardiac efficiency.
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Akira Wakabayashi (1963) studied this question.
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