What question did this study set out to answer?

To review the mechanisms, formulation strategies, and therapeutic applications of mucoadhesive buccal drug delivery systems for prolonged drug release and improved bioavailability.

August 7, 2025International Journal of Progressive Research in Engineering Management and ScienceOpen Access

Review on mucoadhesive buccal drug delivery system

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Authors

KPKrishi PatelUniversity of Ghana NPN. M. PatelMotilal Nehru National Institute of Technology

Discussion

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Implication

Narrative review demonstrates enhanced drug bioavailability and prolonged release via buccal mucoadhesion, highlighting polymer selection as critical for clinical efficacy.

Key Points

To review the mechanisms, formulation strategies, and therapeutic applications of mucoadhesive buccal drug delivery systems for prolonged drug release and improved bioavailability.
Evaluated mechanisms of interfacial bioadhesion between delivery systems, mucin molecules, and the oral mucosal epithelium.
Surveyed diverse mucoadhesive dosage forms, including tablets, patches, films, microspheres, and nanoparticles designed for local and systemic drug delivery.
Buccal mucoadhesion significantly extends formulation residence time at mucosal surfaces, yielding sustained drug release and increased plasma drug concentrations.
Formulations show effective utility across systemic indications and local disorders, including gastrointestinal, ocular, and vaginal conditions, with efficacy governed by polymer properties and delivery system geometry.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/6a1e6cdafe0256fbba329c92 https://doi.org/10.58257/ijprems43245

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Implication

Narrative review demonstrates enhanced drug bioavailability and prolonged release via buccal mucoadhesion, highlighting polymer selection as critical for clinical efficacy.

Review on mucoadhesive buccal drug delivery system

Discussion

Member takes

Implication

Key Points

Cite This Study

Review on mucoadhesive buccal drug delivery system

Discussion

Member takes

Implication

Key Points

Cite This Study

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